Five years after its introduction, Mercedes‑Benz reworked the SL, which it unveiled in 2006 at the International Motor Show in Geneva. The engines, drive train, and chassis were sportier.

The V8 engine (M 273) in the SL 500 was a new design with a displacement of 5.5 litres and an output of 285 kW (388 hp)  that accelerated the vehicle from 0 to 100 km/h in 5.4 seconds. In the US, the vehicle was marketed as SL 550.

The six-cylinder engine in the SL 350 had also been redesigned. The output of the 200 kW (272 hp) V6 engine (M 272) had increased by 11 percent and its fuel consumption decreased by more than 1 litre per 100 km. NEDC combined consumption was 10.3 litres per 100 km. The SL 350 accelerated from 0 to 100 km in 6.6 seconds, making it more than half a second faster than the previous model.

The leader of the pack was the V12 twin-turbo SL 600. Its output increased to 380 kW (517 hp) and its maximum torque to 830 Nm. The SL's 12-cylinder engine accelerated from 0 to 100 km/h in 4.5 seconds.

Mercedes‑Benz equipped the refreshed V6 and V8 models with the 7-speed automatic transmission 7G-TRONIC. The Active Body Control ABC (standard in the SL 500 and SL 600, optional in the SL 350) had also been enhanced. Compared with the previous model, the body moved 60% less in dynamic driving situations.

Subtle design changes to the body included the new bumper with three large cooling air intakes, a more pronounced arrow shape and fog lights set in chrome rings. The new matt-silver radiator grille had three chromed louvers. The new light-alloy wheels were absolute eye catchers. The horizontally divided tail lights with red-and-white clear-glass covers underlined the width of the SL's muscular rear even more.

The restyling in the passenger compartment included a softer grain of leather upholstery, new colours, embossed aluminium trims and metal door sills with embossed Mercedes‑Benz lettering.

From 2007, the SL 350 and SL 500 could be equipped with an optional Sports Package for €2,975. The highlights included silver contrast stitching, perforated leather and aluminium trims. The car's look was also determined by 19-inch five-spoke light-alloy wheels that revealed silver-coated brake callipers. Drilled brake discs on the rear contributed to excellent deceleration values. The automatic transmission 7G-TRONIC Sport with shift paddles on the steering wheel was also part of the standard equipment package. The distinguishing features included smoked tail lights.

The R 230 series was extensively redesigned in 2008. One of the biggest changes was the new front end. The SL 280 and the SL 63 AMG were also introduced.

00023811 SL, Roadster - R 230, with Head of overall Vehicle Development, Frank Knothe
00049580 SL 55 AMG, Roadster - R 230
00049582 SL 55 AMG, Roadster - R 230
00049601 SL 65 AMG, SL 55 AMG, Roadster - R 230
00049633 SL 65 AMG, Roadster - R 230
00049644 SL 65 AMG, Roadster - R 230
00049679 SL 55 AMG, Roadster - R 230
00054440 SL, Roadster - R 230
00054442 SL, Roadster - R 230
00054443 SL, Roadster - R 230
00054444 SL, Roadster - R 230
00054447 SL, Roadster - R 230
00056279 SL 500, Roadster - R 230
00056282 SL, Roadster - R 230
00056371 SL 350, SL 500, Roadster - R 230
00056377 SL, Roadster - R 230
00056405 SL 350, Roadster - R 230
00056407 SL 500, Roadster - R 230
00056420 SL 500, Roadster - R 230
00105908 SL 55 AMG, Roadster - R 230
00172007 SL 65 AMG, SL 55 AMG, Roadster - R 230
00172006 SL 65 AMG, SL 55 AMG, Roadster - R 230
00172018 Mercedes-Benz at the 2006 Geneva Motor Show
00172172 CLS 63 AMG, 4-door Coupé - C 219, SL 55 AMG, Roadster - R 230, SLK 55 AMG, Roadster - R 171
00172185 incenio designer wheel range, 2006
00172280 SL, Roadster - R 230
00172281 SL, Roadster - R 230
00113617 SL, Roadster - R 230, SLK, Roadster - R 171, CLS, 4-door Coupé - C 219
A2003F9555 SL 350, Roadster - R 230
A2003F10199 SLK 350, Roadster - R 171
00188258 SL 55 AMG Roadster - R 230
00188259 SL 55 AMG Roadster - R 230
00188260 SL 55 AMG Roadster - R 230
00188261 SL 55 AMG Roadster - R 230
00188262 SL 55 AMG Roadster - R 230
00188263 SL 55 AMG Roadster - R 230
00188264 SL 55 AMG Roadster - R 230
00188265 SL 55 AMG Roadster - R 230
00188266 SL 55 AMG Roadster - R 230
00188267 SL 55 AMG Roadster - R 230