Born at Sydnope Hall near Matlock in Derbyshire, Loraine-Barrow lived in Biarritz, France, and discovered himself in motorsport. In 1900, he competed in a few races driving Panhard and came into contact with Emil Jellinek in 1901. In 1901 and 1902, he competed in Nice Week in Mercedes vehicles and in 1901 he set a world speed record over the mile with a standing start in the Mercedes 35 hp, achieving an average of 79.7 km/h. The following year, he won the Nice - La Turbie hill climb in the category of four-seater touring cars up to 1000 kg.
A year later, in a French De Dietrich racing car, he took part in the Paris-Madrid long-distance race, which was marked by numerous accidents, and crashed into a tree at 120 km/h in the town of Libourne while trying to avoid a dog running onto the road. His mechanic was killed instantly, his car was totalled and he himself was taken to hospital unconscious. Twenty days later, Loraine-Barrow succumbed to pneumonia, which had set in due to his severe injuries.